Fetal programming of cardiovascular function through exposure to maternal undernutrition
نویسندگان
چکیده
منابع مشابه
Fetal programming of cardiovascular function through exposure to maternal undernutrition.
A substantial and robust body of epidemiological evidence indicates that prenatal dietary experience may be a factor determining cardiovascular disease risk. Retrospective cohort studies indicate that low birth weight and disproportion at birth are powerful predictors of later disease risk. This prenatal influence on non-communicable disease in later life has been termed programming. Maternal n...
متن کاملCALL FOR PAPERS Fetal Physiological Programming Programming of adult cardiovascular function after early maternal undernutrition in sheep
G. S. Gopalakrishnan, D. S. Gardner, S. M. Rhind, M. T. Rae, C. E. Kyle, A. N. Brooks, R. M. Walker, M. M. Ramsay, D. H. Keisler, T. Stephenson, and M. E. Symonds Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham NG7 2UH; School of Biosciences, University of Nottingham, Sutton Bonington Campus, Nottingham LE12 5RD; Macaulay Institute, Craigi...
متن کاملProgramming of adult cardiovascular function after early maternal undernutrition in sheep.
The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate the association between maternal nutrient intake and blood pressure in the resulting adult offspring. No study to date has shown programming of adult cardiovascular function in the sheep through maternal dietary intervent...
متن کاملProgramming hyperglycaemia in the rat through prenatal exposure to glucocorticoids-fetal effect or maternal influence?
In a previous study, we showed that exposure of rats to dexamethasone (Dex) selectively in late pregnancy produces permanent induction of hepatic phosphoenolpyruvate carboxykinase (PEPCK) expression and hyperglycaemia in the adult offspring. The mechanisms by which glucocorticoids cause this programming are unclear but may involve direct actions on the fetus/neonate, or glucocorticoids may act ...
متن کاملImpact of maternal obesity on fetal programming of cardiovascular disease.
The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to m...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 2001
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns2001111